The first benzodiazepine was chlordiazepoxide, and it was introduced in 1960 to treat insomnia, general anxiety disorder (GAD), seizures, alcohol withdrawal, and panic attacks.

Benzodiazepines work by enhancing the effect of the neurotransmitter GABA. The drugs contain chemicals that aid in the calming effect already produced by the human body and keep the brain in a more tranquilized state.

Common name brands include:

  • Alprazolam (Xanax)
  • Chlordiazepoxide (Librium)
  • Clobazam (Onfi)
  • Clonazepam (Klonopin)
  • Clorazepate (Tranxene)
  • Diazepam (Valium)
  • Estalazom (ProSom)
  • Flurazepam (Dalmane)
  • Lorazepam (Ativan)
  • Midazolam (Versed)
  • Oxazepam (Serax)
  • Temazepam (Restoril)
  • Triazolam (Halcion)

Benzodiazepines are controlled substances and a classified as schedule IV drugs.  When combined with other drugs or alcohol there is a significant drug interaction leading to a synergistic effect.  (Synergism is the combined effect of adding similar types of drugs together, but their sum is greater than if the drug was used individually.)   Benzodiazepines and alcohol, which are both depressants, when taken together, can be deadly.  Benzodiazepine overdoses are very common; however, the incidence of death from an overdose when the drug is used by itself is rare.

There are three different classes of benzodiazepines:  Short-acting – Triazolam, intermediate-acting – Alprazolam, and long-acting – Diazepam.

The use of Benzodiazepines for more than 3-6 weeks may lead to physical cravings and tolerance.  Long-term use of 6-12 months could lead to addiction.  Benzodiazepine withdrawal can begin within 2-3 days after cessation.  Signs and symptoms can include:

  • Anxiety
  • Autonomic hyperactivity, e., diaphoresis, tachycardia
  • Grand mal seizures
  • Hand tremor
  • Insomnia
  • Nausea or vomiting
  • Psychomotor agitation
  • Transient auditory, tactile, or visual hallucinations or illusions

Benzodiazepines should be tapered off by a doctor or a hospital over a period of 4-6 weeks.  However, complete withdrawal may take months to years.  If someone has become dependent on benzodiazepines, it is crucial that they do not suddenly stop cold turkey.

Flumazenil – Has been used as an antidote in the treatment of benzodiazepine overdoses.  It reverses the effects of benzodiazepines by competing with the benzodiazepine on the binding site of the GABAA receptor.   Flumazenil is used to reverse the sedative effects of a benzodiazepine during surgery or other procedures.   Flumazenil is also used to treat benzodiazepine overdose.

It is very difficult to recover from benzodiazepine addiction because these drugs change the chemistry of the brain. Contact a drug addiction treatment center if you or a loved one is suffering from an addiction.


Johnina Noar, CADC-II
AToN Center  888-535-1516